GENETIC POLYMORPHISMS OF THE PRL AND PRLR GENES IN PATIENTS WITH BREAST CANCER AND HYPERPROLACTINEMIA

Despite the accumulated evidence regarding the role of hyperprolactinemia (HPRL) in the pathogenesis of breast cancer (BC), the genetic determinants of this condition remain insufficiently investigated. Single nucleotide polymorphisms (SNPs) in the PRL and PRLR genes may influence the regulation of prolactin-dependent signaling pathways by altering prolactin expression, the functional activity of its receptor, and the characteristics of intercellular signal transduction. Consequently, these genetic variants may contribute to differences in tumor progression, pa­tients’ hormonal status, and response to anticancer therapy.