MOLECULAR GENETIC SIGNIFICANCE OF THE VEGFA C-634G GENE POLYMORPHISM IN PREDICTING THE RISK OF CHRONIC HEART FAILURE DEVELOPMENT IN PATIENTS WITH ISCHEMIC HEART DISEASE

Chronic heart failure (CHF) developing on the background of ischemic heart disease (IHD) remains one of the leading causes of disability and mortality worldwide. Identification of molecular genetic factors associated with the development and progression of the disease is essential for the early detection of high-risk patients and the implementation of personalized prevention and treatment strategies. This article evaluates the molecular genetic significance of the VEGFA C-634G gene polymorphism in predicting the risk of CHF development in patients with IHD. The distribution of alleles and genotypes of the polymorphism, as well as their associations with clinical and functional parameters, were analyzed. The findings suggest that the VEGFA C-634G polymorphism may serve as an additional molecular genetic marker for assessing the risk of CHF development and the severity of its clinical course.

Genotyping of the VEGFA C-634G polymorphism was performed using a commercial assay kit manufactured by Synthol LLC (Russia) on the Rotor-Gene Q real-time PCR system (QIAGEN, Germany).