RESULTS OF THE STUDY ON THE ANDROGENIC STATUS OF MEN WITH TYPE 2 DIABETES MELLITUS

The aim of the study was to investigate the androgen status in patients with type 2 diabetes mellitus.

Material and methods of the study. The study included 70 men aged 42 to 60 years with an average age of 46.3 ± 3.5 years. The control group consisted of 20 healthy individuals. The patients were divided into 2 groups: Group 1 - patients with type 2 diabetes mellitus in a state of carbohydrate metabolism compensation - 35 people, Group 2 - patients with type 2 diabetes mellitus in a state of carbohydrate metabolism decompensation - 35 people. The control group consisted of healthy individuals - 20 men of the same age.

The research methods included general clinical, biochemical (study of glycemia, glycated hemoglobin (HbA1c), lipid spectrum,bilirubin, direct, indirect, ALT, AST, PTI, etc.), hormonal (LH, FSH, free testosterone, prolactin, free thyroxine, TSH), anthropometric calculations (height (cm), weight (kg), BMI (kg/m2), WC, HC), and instrumental methods: ECG, thyroid and gonads ultrasound, chest x-ray.

Research results. In a study of 70 people, testosterone deficiency was diagnosed in 35% of participants. Comparative analysis showed that in patients with type 2 diabetes mellitus, testosterone levels were statistically sig­nificantly lower than in healthy individuals (p < 0.001). When comparing the groups with normal and low testosterone levels, it was found that individuals with hormone deficiency had significantly higher fasting glucose (p = 0.0019) and glycated hemoglobin (HbA1c; p = 0.0449) levels. Pearson correlation analysis confirmed the presence of an inverse relationship: in men with diabetes, the level of total serum testosterone negatively correlates with both fasting glucose (r = -0.252, p = 0.001) and HbA1c (r = -0.697, p = 0.001).

This study shows that diabetes mellitus causes low testosterone levels in men, and low testosterone levels can serve as a marker of diabetes mellitus.

Conclusions. In a study of 70 people with type 2 diabetes, testosterone deficiency was diagnosed in 25 (35.7%) participants. The majority of these were in group 2 – 18 of the 25 patients (72%).